Relation of sodium balance to arterial pressure during drug-induced saluresis.
نویسندگان
چکیده
Serial determinations of plasma volume and urinary sodium excretion were determined during saluresis in 20 hypertensive patients. Although the diuretics produced a decrease in plasma volume and an increase in urinary sodium excretion in all patients, there was no direct relationship between the decrease in plasma volume and the fall in arterial pressure. Concomitant administration of dextran solution prevented the reduction in plasma volume but did not prevent the fall in arterial pressure. Similarly, replacement of plasma volume with dextran solution at the peak of hypotension following the diuretics had no effect on the reduced arterial pressure. Concomitant administration of hypertonic saline solution with the diuretic prevented the fall in arterial pressure, and the replacement of urinary sodium loss at the peak-of hypotension returned the arterial pressure to control values when the sodium administered exceeded the urinary sodium loss. It would seem that in the hypertensive sodium depleted state a direct relationship exists between arterial pressure and sodium balance. Thus, a positive sodium balance is associated with a rise in arterial pressure, whereas a negative sodium balance is associated with a fall in arterial pressure. The data suggest also that the decreased pressor response during saluresis is due more to the production of negative sodium balance than to a decrease in plasma volume.
منابع مشابه
Relationships among intravascular volume, total body sodium, arterial pressure, and vasomotor tone.
CHLOROTHIAZIDE administration in normotensive and hypertensive individuals causes saluresis, diuresis, oligemia, increased depressor responses to ganglioplegics, and decreased pressor responses to norepinephrine."" These changes in responses to vasoactive drugs are abolished if plasma volume is expanded by salt-free dextran,^* and we have suggested that they reflect an augmented sympathetic vas...
متن کاملRelation between sodium intake, renal function, and the regulation of arterial pressure.
The long-term regulation of arterial pressure requires the maintenance of a balance between sodium and water intake and sodium and water excretion. Normal salt and water balance leads to stable body fluid volumes and the maintenance of normal renal function is critical to establishing extracellular fluid volume homeostasis. This review focuses on the role of the kidney in the long-term control ...
متن کاملEffect of arterial baroreceptor denervation on sodium balance.
During chronic increased dietary sodium intake, arterial baroreceptors buffer against sustained increases in arterial pressure, and renal sympathoinhibition contributes importantly to the maintenance of sodium balance by decreasing renal tubular sodium reabsorption and increasing urinary sodium excretion. The present study examined the effect of arterial baroreceptor denervation on sodium balan...
متن کاملNitric oxide regulates renal hemodynamics and urinary sodium excretion in dogs.
The goal of this study was to determine whether nitric oxide has a long-term role in the control of renal hemodynamics and the relation between arterial pressure and urinary sodium excretion. Studies were conducted over a 25-day period in seven conscious dogs equipped with indwelling vascular catheters and an electromagnetic flow probe on the iliac artery. Nitric oxide synthesis was inhibited b...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Circulation
دوره 37 2 شماره
صفحات -
تاریخ انتشار 1968